Sounds like an Anitvirus of Firewall issue, disable them and try again, or try Windows Safe Mode
I just set up and installed a Documate 3220 and connected it to my Windows 10 Pro system via the supplied USB cable. Both the native software and the PaperPort originally sees the scanner. Regardless of what type of scan I ask it to perform, it begins the scan and either just before or right after physically finishes scanning the document, I hear the scaner disconnect from the computer (the USB disconect tone sounds). A second later, it reconnects (the USB device connected sound plays). About 15 seconds later, either nothing happens and no PDF (or anything else) is produced, or an error message stated the computer can't communicate with the scanner appears (also, no output is produced).
I've tried various different profile settings in the software to no avail.
Any ideas?