Hi AMitch,
Thank you for using the Support Forum. Please take a look a this article Scan to Email Using Office 365 from the online support for your printer. If these steps do not help please consider contacting your support centre for further assistance.
Having issues with a SMTP relay through O365 for a user. Currently SMTP auth is set to use a users account, however, it looks like the SMTP checks are pulling an alias of the account for testing. Not sure if this is the pain point, but either way the S2E is not functioning. All other SMTP settings appear correct.