It depends and it usually takes a bit of professional services.
If you are looking for something like FreeFlow MakeReady in which you open a document and define the job ticketing using a visual UI then you should look at FFMakeReady since that's the best tool for the job.
However, if you want to pull content out of a CMS have tabs and exceptions built on the fly so the job arrives at the printer with a full ticket then that's doable. As long as the rules for creating the print ticket and inserting the tabs and annotations are consistent you can usually have a custom solution built around FFCore to fully automate the setup of the job.
In the later case I would suggest you contact your local analyst or the solutions engagement team.
I have seen them do this before and if the details make it a fit I am sure they can do it again.